免疫毒素及其他偶联物：临床前研究

Immunotoxins and other conjugates: pre-clinical studies.

作者信息

Bolognesi A, Polito L

机构信息

Department of Experimental Pathology, University of Bologna, Italy.

出版信息

Mini Rev Med Chem. 2004 Jun;4(5):563-83. doi: 10.2174/1389557043403864.

DOI:10.2174/1389557043403864

PMID:15180511

Abstract

A wide variety of conjugates containing RIPs, of either chemical or recombinant type, have been made and tested against dangerous cells in vitro and in animal models. Many of these pre-clinical studies will be reviewed here dividing them on the basis of the target cell and the surface molecule specifically recognized.

摘要

已经制备了各种各样含有化学或重组类型核糖体失活蛋白（RIPs）的缀合物，并在体外和动物模型中针对危险细胞进行了测试。这里将回顾许多这些临床前研究，并根据靶细胞和特异性识别的表面分子对它们进行分类。