齐拉西酮与氯氮平联合治疗难治性精神分裂症

Combination of ziprasidone and clozapine in treatment-resistant schizophrenia.

作者信息

Zink M, Mase E, Dressing H

机构信息

Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany.

出版信息

Hum Psychopharmacol. 2004 Jun;19(4):271-3. doi: 10.1002/hup.580.

DOI:10.1002/hup.580

PMID:15181656

Abstract

In cases of treatment-resistant schizophrenia the combined application of antipsychotic drugs often becomes necessary. Clozapine has been combined successfully with other atypical antipsychotic drugs such as risperidone or amisulpride in the past. We report the difficult treatment of a 28-year-old schizophrenic woman. Psychotic symptoms were found resistant to monotherapy with clozapine or ziprasidone. In contrast, combined application led to a marked improvement in both positive and negative symptoms of schizophrenia along with a decrease of side effects.The reported combination is a promising option in cases of treatment-resistant schizophrenia and should be further evaluated in prospective studies.

摘要

在难治性精神分裂症的病例中，抗精神病药物的联合应用常常成为必要。过去，氯氮平已成功地与其他非典型抗精神病药物如利培酮或氨磺必利联合使用。我们报告了一名28岁精神分裂症女性的难治性治疗情况。发现其精神病症状对氯氮平或齐拉西酮单一疗法耐药。相比之下，联合应用导致精神分裂症的阳性和阴性症状均有显著改善，同时副作用减少。所报道的联合用药在难治性精神分裂症病例中是一个有前景的选择，应在前瞻性研究中进一步评估。