氨磺必利与氯氮平联合用于难治性精神分裂症患者。
Combined use of amisulpride and clozapine for patients with treatment-resistant schizophrenia.
作者信息
Cook Brian, Hoogenboom Gerry
机构信息
Bundaberg Integrated Mental Health Service, Bundaberg, Queensland 4670, Australia.
出版信息
Australas Psychiatry. 2004 Mar;12(1):74-6. doi: 10.1046/j.1039-8562.2003.02064.x.
OBJECTIVE
To report on a trial of adding amisulpride to clozapine.
METHODS
Description of six cases.
RESULTS
Six patients who had been on clozapine were commenced on amisulpride. All patients had had unwanted effects with clozapine, particularly sedation, hypersalivation, or weight gain. Five patients reported a high level of satisfaction with the regimen, having a reduction in the level of sedation and improvement in levels of motivation and energy, without recurrence of positive symptoms.
CONCLUSION
The combined use of amisulpride and clozapine would appear to be an appropriate and beneficial treatment.
目的
报告一项关于在氯氮平基础上加用氨磺必利的试验。
方法
描述6例病例。
结果
6例服用氯氮平的患者开始加用氨磺必利。所有患者服用氯氮平均出现了不良反应，尤其是镇静、唾液分泌过多或体重增加。5例患者对该治疗方案表示高度满意，镇静程度减轻，动力和精力水平有所改善，且阳性症状未复发。
结论
氨磺必利与氯氮平联合使用似乎是一种合适且有益的治疗方法。
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