儿童阻塞性睡眠呼吸暂停综合征:最新综述

Obstructive sleep apnea syndrome in children: a state-of-the-art review.

作者信息

Erler Thomas, Paditz Ekkehart

机构信息

Department of Pediatrics, Carl-Thiem-Klinikum, Cottbus, Germany.

出版信息

Treat Respir Med. 2004;3(2):107-22. doi: 10.2165/00151829-200403020-00005.

Abstract

Snoring and obstructive sleep apnea are a frequent problem not only in adults, but also in children and adolescents, as can be seen from current epidemiological data. The epidemiology, etiology, diagnosis, and management of obstructive sleep apnea syndrome (OSAS) in adults have been adequately established on the basis of evidential data. As a result of this, both physicians and the public are increasingly aware of OSAS in adults. Although there are numerous parallels between pediatric and adult OSAS, the situation in children differs that in adults. There is a greater variety of symptoms in children with OSAS, diagnosis is often more difficult with serious consequences for growth and development of children. Treatment of OSAS in children is also different from that of the adult patient. There are many possible causes for the development of obstructive sleep apnea in children. These include hypertrophy of the tonsils and syndromes such as Down syndrome, Pickwickian syndrome, Prader-Willi syndrome or Marfan syndrome. OSAS can, however, also be the result of obesity, midfacial dysplasia, retro- or micrognathia, allergic rhinitis or muscular dystrophy. Epidemiological data presented in the literature concerning the incidence of OSAS in children is extremely varied. This wide range is probably due to the fact that snoring may be misdiagnosed as OSAS. The diagnosis of OSAS in children may only be made by considering clinical history (such as rate of growth, tendency to fall asleep during the day, sleep disturbances, susceptibility to infection, etc.), polysomnography (if possible during several nights) and accompanying instrumental diagnosis including cephalometry or laryngoscopy. One of the problems of polysomnography in childhood is that performance and interpretation of the results have not yet been standardized or evaluated for different age groups. Treatment depends on the cause of OSAS and require multidisciplinary management involving the pediatrician, pediatric or adolescent psychiatrist, ear, nose, and throat specialist, maxillofacial surgeons, and neurosurgeons. Adenotonsillectomy (ATE) is the therapy generally chosen if the child has adenoidal vegetations and/or tonsillar hypertrophy. Corrective surgery is possible for rare malformation syndromes. Nocturnal masks for continuous positive airway nasal pressure or procedures for mask respiration are effective in children, but are only used in exceptional cases, such as when ATE is contraindicated or when symptoms of OSAS remain after surgery. The success of pharmacological treatment of OSAS in children has not been evaluated in controlled clinical trials.

摘要

从目前的流行病学数据可以看出,打鼾和阻塞性睡眠呼吸暂停不仅在成年人中是常见问题,在儿童和青少年中也是如此。基于确凿的数据,成人阻塞性睡眠呼吸暂停综合征(OSAS)的流行病学、病因、诊断和管理已得到充分确立。因此,医生和公众对成人OSAS的认识日益提高。尽管儿童和成人OSAS有许多相似之处,但儿童的情况与成人不同。OSAS患儿的症状更为多样,诊断往往更困难,对儿童的生长发育会产生严重后果。儿童OSAS的治疗也与成人患者不同。儿童发生阻塞性睡眠呼吸暂停有许多可能的原因。这些原因包括扁桃体肥大以及唐氏综合征、匹克威克综合征、普拉德 - 威利综合征或马凡综合征等综合征。然而,OSAS也可能是肥胖、面中部发育异常、下颌后缩或小颌畸形、过敏性鼻炎或肌肉萎缩症的结果。文献中给出的关于儿童OSAS发病率的流行病学数据差异极大。这种广泛的差异可能是因为打鼾可能被误诊为OSAS。儿童OSAS的诊断只能通过考虑临床病史(如生长速度、白天入睡倾向、睡眠障碍、易感染性等)、多导睡眠图(如有可能在几个晚上进行)以及包括头影测量或喉镜检查在内的辅助仪器诊断来进行。儿童多导睡眠图的问题之一是,其操作和结果解读尚未针对不同年龄组进行标准化或评估。治疗取决于OSAS的病因,需要多学科管理,涉及儿科医生、儿童或青少年精神科医生、耳鼻喉科专家、颌面外科医生和神经外科医生。如果儿童有腺样体肥大和/或扁桃体肥大,通常会选择腺样体扁桃体切除术(ATE)。对于罕见的畸形综合征,可以进行矫正手术。夜间持续气道正压通气面罩或面罩呼吸程序对儿童有效,但仅在特殊情况下使用,例如ATE禁忌或手术后仍有OSAS症状时。儿童OSAS药物治疗的效果尚未在对照临床试验中进行评估。

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