Jacobsen Anne Flem, Drolsum Anders, Klow Nils Einar, Dahl Gunn Fallås, Qvigstad Erik, Sandset Per Morten
Department of Obstetrics and Gynecology, Ullevål University Hospital, Kirkeveien 166, N-0407 Oslo, Norway. anneflem@
Thromb Res. 2004;113(5):283-8. doi: 10.1016/j.thromres.2004.03.008.
Pregnancy is associated with an overall 5-10 fold increased risk of venous thromboembolism (VTE). The absolute risk is highest during and shortly after delivery. Although operative delivery further increases the risk of VTE, there is no consensus on thromboprophylaxis after an elective cesarean. The aim of the present study was to investigate the frequency of symptomatic and asymptomatic deep venous thrombosis (DVT) in a low risk cesarean section population.
Fifty-nine women undergoing elective cesarean section were screened for DVT using triplex Doppler sonography 3-5 days after delivery. Markers of activated coagulation were also followed and all women were screened for thrombophilia. Postoperative thromboprophylaxis was not given. During the same period all cases of symptomatic VTE were also recorded.
No DVT was detected by ultrasonography and no women developed symptomatic VTE during the six weeks follow-up period after delivery. Six women had thrombophilia. During the study period, a cesarean section was performed in 1067/5364 (20%) deliveries. Five of these women (0.47%) developed symptomatic pulmonary embolism, and all of these women had additional risk factors for VTE.
The risk of DVT among healthy pregnant women undergoing elective cesarean section is low, and general medical thromboprophylaxis is probably not justified.
妊娠与静脉血栓栓塞症(VTE)的总体风险增加5至10倍相关。绝对风险在分娩期间及产后不久最高。尽管手术分娩会进一步增加VTE的风险,但对于择期剖宫产术后的血栓预防尚无共识。本研究的目的是调查低风险剖宫产人群中有症状和无症状深静脉血栓形成(DVT)的发生率。
59例行择期剖宫产的妇女在产后3至5天使用三联多普勒超声检查DVT。还跟踪了活化凝血指标,并且对所有妇女进行了易栓症筛查。未给予术后血栓预防措施。在同一时期,还记录了所有有症状VTE的病例。
在产后六周的随访期内,超声检查未发现DVT,也没有妇女发生有症状的VTE。6名妇女患有易栓症。在研究期间,1067/5364(20%)的分娩进行了剖宫产。其中5名妇女(0.47%)发生了有症状的肺栓塞,并且所有这些妇女都有VTE的其他危险因素。
择期剖宫产的健康孕妇发生DVT的风险较低,一般药物性血栓预防可能不合理。