免疫增强预防极低出生体重儿医院获得性凝固酶阴性葡萄球菌败血症
Immunoenhancement to prevent nosocomial coagulase-negative staphylococcal sepsis in very low-birth-weight infants.
作者信息
Devlin Lori A, Lassiter Herbert A
机构信息
Division of Neonatal Medicine, Department of Pediatrics, University of Louisville School of Medicine, 571 S. Floyd St., Suite 300, Louisville, KY 40202-3830, USA.
出版信息
Clin Perinatol. 2004 Mar;31(1):69-75. doi: 10.1016/j.clp.2004.03.010.
Extremely low-birth-weight infants are susceptible to invasion by coagulase-negative staphylococci (CONS). This article reviews the epidemiology, immunology, and microbiology of CONS and describes recent clinical trials of immunoenhancing agents such as intravenous immunoglobulin, granulocyte colony-stimulating factor, granulocyte macrophage colony-stimulating factor, and mouse humanized chimeric anti-lipoteichoic acid antibody. Potential avenues of research to reduce the incidence of nosocomial CONS sepsis in premature neonates are presented.
极低出生体重儿易受凝固酶阴性葡萄球菌（CONS）侵袭。本文综述了CONS的流行病学、免疫学和微生物学，并描述了免疫增强剂如静脉注射免疫球蛋白、粒细胞集落刺激因子、粒细胞巨噬细胞集落刺激因子和鼠源人源化嵌合抗脂磷壁酸抗体的近期临床试验。还提出了降低早产儿医院获得性CONS败血症发病率的潜在研究途径。
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