通过比较基因组杂交检测少突胶质细胞瘤中的染色体失衡。

Chromosome imbalances in oligodendroglial tumors detected by comparative genomic hybridization.

作者信息

Bourdon Violaine, Plessis Ghislaine, Chapon Françoise, Guarnieri José, Derlon Jean Michel, Jonveaux Philippe

机构信息

Laboratoire de Génétique-EA3441, CHU Nancy-Brabois, avenue du Morvan, 54111 Vandoeuvre les Nancy, France.

出版信息

Ann Genet. 2004 Apr-Jun;47(2):105-11. doi: 10.1016/j.anngen.2003.10.002.

DOI:10.1016/j.anngen.2003.10.002

PMID:15183742

Abstract

Seven well-differentiated oligodendrogliomas, 16 anaplastic oligodendrogliomas and two cases of oligoastrocytomas were investigated by comparative genomic hybridization (CGH) on frozen tissue samples. The most frequent losses found involved 1p and 19q in 32% of cases. Loss of 9p was observed during malignant progression in 25% of anaplastic oligodendrogliomas. In two anaplastic oligodendrogliomas gain of 1q was found. The frequent losses of chromosome 16 and 22 have not been reported previously. These results underscore that CGH is a powerful tool for the classification of gliomas complementing the traditional histopathological approach.

摘要

对7例高分化少突胶质细胞瘤、16例间变性少突胶质细胞瘤和2例少突星形细胞瘤的冷冻组织样本进行了比较基因组杂交（CGH）研究。最常见的缺失发生在32%的病例中，涉及1p和19q。在25%的间变性少突胶质细胞瘤的恶性进展过程中观察到9p缺失。在2例间变性少突胶质细胞瘤中发现了1q增益。此前尚未报道过16号和22号染色体的频繁缺失。这些结果强调，CGH是一种强大的胶质瘤分类工具，可补充传统的组织病理学方法。