新型1-[2-(苯并恶唑-2-基)乙氧基]-2,6-二芳基哌啶-4-酮的合成及其抗菌和抗真菌活性研究
Synthesis and study of antibacterial and antifungal activities of novel 1-[2-(benzoxazol-2-yl)ethoxy]- 2,6-diarylpiperidin-4-ones.
作者信息
Ramalingan C, Balasubramanian S, Kabilan S, Vasudevan M
机构信息
Department of Chemistry, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India.
出版信息
Eur J Med Chem. 2004 Jun;39(6):527-33. doi: 10.1016/j.ejmech.2004.02.005.
Some novel benzoxazolylethoxypiperidones have been synthesized and their antibacterial activity against streptococcus faecalis, bacillus subtilis, escherichia coli, staphylococcus aureus aand pseudomonas aeruginosa and antifungal activity against Candida-6, Candida albicans, Aspergillus niger, Candida-51 and Aspergillus flavus were evaluated. Compounds 37, 38 and 39 exerted potent in vitro antibacterial activity against Streptococcus faecalis while compounds 40 and 41 exhibited potent in vitro antifungal activity against Candida-51.
已合成了一些新型苯并恶唑基乙氧基哌啶酮，并评估了它们对粪肠球菌、枯草芽孢杆菌、大肠杆菌、金黄色葡萄球菌和铜绿假单胞菌的抗菌活性以及对假丝酵母6型、白色念珠菌、黑曲霉、假丝酵母51型和黄曲霉的抗真菌活性。化合物37、38和39对粪肠球菌具有强大的体外抗菌活性，而化合物40和41对假丝酵母51型具有强大的体外抗真菌活性。
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