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新型8-甲基-7,9-二芳基-1,2,4,8-四氮杂螺[4.5]癸烷-3-硫酮的抗菌和抗真菌活性的合成与研究

Synthesis and study of antibacterial and antifungal activities of novel 8-methyl-7,9-diaryl-1,2,4,8-tetraazaspiro[4.5]decan-3-thiones.

作者信息

Balasubramanian S, Ramalingan C, Aridoss G, Kabilan S

机构信息

Department of Chemistry, Annamalai University, Annamalainagar, Tamil Nadu 608 002, India.

出版信息

Eur J Med Chem. 2005 Jul;40(7):694-700. doi: 10.1016/j.ejmech.2005.02.001.

Abstract

Some novel spiropiperidinyl-1,2,4-triazolidin-3-thiones have been synthesized and studied for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and antifungal activity against Candida albicans, Candida-6, Candida-51, Aspergillus niger and Aspergillus flavus. Compounds 30-32 exhibited potent in vitro antibacterial activity against E. coli and P. aeruginosa whereas the same set of compounds exerted potent in vitro antifungal activity against Candida-6, A. niger and A. flavus.

摘要

已经合成了一些新型的螺哌啶基-1,2,4-三唑烷-3-硫酮,并研究了它们对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌和铜绿假单胞菌的抗菌活性以及对白色念珠菌、念珠菌-6、念珠菌-51、黑曲霉和黄曲霉的抗真菌活性。化合物30-32对大肠杆菌和铜绿假单胞菌表现出强大的体外抗菌活性,而同一组化合物对念珠菌-6、黑曲霉和黄曲霉表现出强大的体外抗真菌活性。

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