Scopinaro Francesco, De Vincentis Giuseppe, Corazziari Enrico, Massa Rita, Osti Mattia, Pallotta Nadia, Covotta Alfredo, Remediani Silvia, Paolo Maria Di, Monteleone Francesco, Varvarigou Alexandra
Department of Scienze Radiologiche, Università La Sapienza Rome, Italy.
Cancer Biother Radiopharm. 2004 Apr;19(2):245-52. doi: 10.1089/108497804323072020.
Breast, prostate, and lung cancer have been successfully detected with 99mTc bombesin (99mTc-leu13-BN1), the radiopharmaceutical that our group developed from synthesis to diagnostic trials. Overexpression of bombesin receptors (BNRs) in colon cancer is well known: the aim of this study was to assess whether or not colon cancer can be detected with a 99mTc-leu13-BN1 scan. Thirteen (13) patients, 7 of whom with known rectal cancer and 6 scheduled to undergo endoscopic removal of polyps for suspicion of colon cancer, were studied with a 99mTc-leu13-BN1 scan. Dynamic, single photon emission computed tomography, and whole-body scans were performed within 1 hour, before discharge of radioactivity from the liver into the duodenum. Sixteen (16) of 17 colorectal cancer locations were detected with a 99mTc-leu13-BN1 scan with 94.1% sensitivity. Six (6) lesions were benign: 1 Crohn's disease, 1 polyp with mild dysplasia, 4 polyps with simple hyperplasia; 99mTc-leu13-BN1 scans were positive in two nontumoral lesions, Crohn's disease, and mild dysplasia and true negative in 4: specificity was 67%. Of the 7 patients with known rectal cancer, 5, who underwent operations instead of radiation therapy, showed lymph-node invasion on 99mTc-leu13-BN1 scans. Operations confirmed the scintigraphic staging. 99mTc-leu13-BN1 is taken up by colon cancer. Scans are sensitive, although scarcely specific. 99mTc-leu13-BN1 allows for node-invasion detection.
我们团队从合成到诊断试验自主研发的放射性药物99mTc 蛙皮素（99mTc-leu13-BN1）已成功用于检测乳腺癌、前列腺癌和肺癌。众所周知，结肠癌中蛙皮素受体（BNRs）过表达：本研究的目的是评估99mTc-leu13-BN1扫描能否检测出结肠癌。对13例患者进行了99mTc-leu13-BN1扫描研究，其中7例已知患有直肠癌，6例因怀疑患有结肠癌而计划接受息肉内镜切除术。在肝脏放射性排入十二指肠之前的1小时内进行了动态、单光子发射计算机断层扫描和全身扫描。17个结直肠癌病灶中有16个通过99mTc-leu13-BN1扫描被检测到，灵敏度为94.1%。6个病灶为良性：1例克罗恩病，1例轻度发育异常息肉，4例单纯增生息肉；99mTc-leu13-BN1扫描在2个非肿瘤性病灶（克罗恩病和轻度发育异常）中呈阳性，在4个病灶中呈真阴性：特异性为67%。在7例已知患有直肠癌的患者中，5例接受了手术而非放疗，99mTc-leu13-BN1扫描显示有淋巴结侵犯。手术证实了闪烁扫描分期。99mTc-leu13-BN1可被结肠癌摄取。扫描具有敏感性，尽管特异性较差。99mTc-leu13-BN1能够检测出淋巴结侵犯。
