Lee Wei-Jei, Huang Ming-Te, Yu Po-Jui, Wang Weu, Chen Tai-Chi
Department of Surgery, En-Chu Kong Hospital, Taiwan.
Obes Surg. 2004 May;14(5):626-34. doi: 10.1381/096089204323093390.
Vertical banded gastroplasty (VBG) and gastric bypass (GBP) are the two bariatric procedures recommended by NIH consensus conference. Recent advancement in laparoscopic (L) techniques has made LVBG and LGBP alternatives for the conventional open approach.
From December 2000 to February 2002, 80 patients (24 men and 56 women; mean age 32 years, range 18-57) with morbid obesity (mean BMI 43.2 kg/m(2), range 36-59.8) were enrolled in a prospective trial and randomly assigned to LVBG or LGBP. Changes in quality of life were assessed using the Gastro-intestinal quality of life index (GIQLI).
The conversion rate was zero for LVBG and 2.5% (1/40) for LGBP. There has been no mortality. Surgical time was significantly longer for LGBP (209 minvs 126 min for LVBG, P<0.001). Mean hospital stay was 3.5 days for the LVBG vs 5.7 days for LGBP (P<0.001). Postoperative analgesic usage was also less for LVBG patients (mean dose 1.4 vs 2.4, P<0.05). Early complication rate was higher in the LGBP group (17.8% vs 2.5%, P<0.001). All 3 major complications were in the LGBP group, of which 2 were related to anastomotic leakage (5%). Late complications consisted of upper GI bleeding, stenosis and others observed in 4 LGBP patients (10%) and 2 LVBG patients (5%). Mean follow-up was 20 months (range 18 to 30). BMI fell significantly in both groups, with significant improvement of obesity-related co-morbidities. LGBP had significantly better excess weight loss than LVBG (62.9% vs 55.4% at 1 year and 71.4% vs 53.1% at 2 years), as well as lower BMI than LVBG (29.6 vs 31.1 at 1 year and 28.5 vs 31.9 at 2 years). There was no difference in the reduction of obesity-related laboratory abnormalities at 1 year except a lower hemoglobin in LGBP (11.8 vs 13.8, P<0.05). Preoperative GIQLI scores were similar between the groups; however, at 1 year, LGBP patients had better GIOLI scores than LVBG patients (121 vs 106, P<0.01). LVBG had improvement in physical condition, social function and emotional conditioning but deterioration in GI symptoms which resulted in no increase in total GIQLI score.
LGBP was a time-consuming demanding technique with a higher early complication rate compared with LVBG. Although both operations resulted in significant weight reduction and decrease in obesity-related co-morbidities, LGBP had a trend of greater weight loss and significantly better GIQLI than LVBG at the cost of a significant long-term trace element deficiency state. Each patient should be individualized for the operations according to the patient's decision.
垂直束带胃成形术(VBG)和胃旁路术(GBP)是美国国立卫生研究院共识会议推荐的两种减肥手术。腹腔镜(L)技术的最新进展使LVBG和LGBP成为传统开放手术的替代方法。
从2000年12月至2002年2月,80例病态肥胖患者(24例男性和56例女性;平均年龄32岁,范围18 - 57岁)(平均BMI 43.2 kg/m²,范围36 - 59.8)被纳入一项前瞻性试验,并随机分配接受LVBG或LGBP。使用胃肠道生活质量指数(GIQLI)评估生活质量的变化。
LVBG的转换率为零,LGBP为2.5%(1/40)。无死亡病例。LGBP的手术时间明显更长(LVBG为126分钟,LGBP为209分钟,P<0.001)。LVBG的平均住院时间为3.5天,LGBP为5.7天(P<0.001)。LVBG患者术后的镇痛药物使用也较少(平均剂量1.4对比2.4,P<0.05)。LGBP组的早期并发症发生率更高(17.8%对比2.5%,P<0.001)。所有3例主要并发症均在LGBP组,其中2例与吻合口漏有关(5%)。晚期并发症包括上消化道出血、狭窄及其他,在4例LGBP患者(10%)和2例LVBG患者(5%)中观察到。平均随访时间为20个月(范围18至30个月)。两组的BMI均显著下降,肥胖相关合并症有显著改善。LGBP的超重减轻明显优于LVBG(1年时为62.9%对比55.4%,2年时为71.4%对比53.1%),且BMI低于LVBG(1年时为29.6对比31.1,2年时为28.5对比31.9)。1年时,除LGBP的血红蛋白较低(11.8对比13.8,P<0.05)外,肥胖相关实验室异常指标的降低无差异。术前两组的GIQLI评分相似;然而,1年时,LGBP患者的GIOLI评分优于LVBG患者(121对比106,P<0.01)。LVBG在身体状况、社会功能和情绪状态方面有改善,但胃肠道症状恶化,导致GIQLI总分未增加。
与LVBG相比,LGBP是一项耗时且要求较高的技术,早期并发症发生率更高。虽然两种手术均导致体重显著减轻和肥胖相关合并症减少,但LGBP有更大的体重减轻趋势,且GIQLI明显优于LVBG,代价是显著的长期微量元素缺乏状态。应根据患者的决定为每位患者制定个体化的手术方案。