p53介导的转录激活：从试管到细胞

p53-mediated transcriptional activation: from test tube to cell.

作者信息

Fingerman Ian M, Briggs Scott D

机构信息

Department of Biochemistry, Purdue University, 175 South University Street, West Lafayette, IN 47907, USA.

出版信息

Cell. 2004 Jun 11;117(6):690-1. doi: 10.1016/j.cell.2004.05.021.

DOI:10.1016/j.cell.2004.05.021

PMID:15186770

Abstract

Posttranslational modifications of histones have been strongly correlated with transcriptional regulation. In this issue of Cell, comprehensively examined the nature of arginine methyltransferases and histone modifications in p53-mediated transcription.

摘要

组蛋白的翻译后修饰与转录调控密切相关。在本期《细胞》杂志中，全面研究了p53介导的转录中精氨酸甲基转移酶的性质和组蛋白修饰。