West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, China.
Cell Oncol (Dordr). 2024 Oct;47(5):1503-1522. doi: 10.1007/s13402-024-00943-9. Epub 2024 Apr 15.
Coactivator-associated arginine methyltransferase 1 (CARM1), pivotal for catalyzing arginine methylation of histone and non-histone proteins, plays a crucial role in developing various cancers. CARM1 was initially recognized as a transcriptional coregulator by orchestrating chromatin remodeling, transcription regulation, mRNA splicing and stability. This diverse functionality contributes to the recruitment of transcription factors that foster malignancies. Going beyond its established involvement in transcriptional control, CARM1-mediated methylation influences a spectrum of biological processes, including the cell cycle, metabolism, autophagy, redox homeostasis, and inflammation. By manipulating these physiological functions, CARM1 becomes essential in critical processes such as tumorigenesis, metastasis, and therapeutic resistance. Consequently, it emerges as a viable target for therapeutic intervention and a possible biomarker for medication response in specific cancer types. This review provides a comprehensive exploration of the various physiological functions of CARM1 in the context of cancer. Furthermore, we discuss potential CARM1-targeting pharmaceutical interventions for cancer therapy.
辅激活因子相关精氨酸甲基转移酶 1（CARM1）在催化组蛋白和非组蛋白蛋白的精氨酸甲基化方面发挥关键作用，是多种癌症发展的关键因素。CARM1 最初被认为是通过协调染色质重塑、转录调控、mRNA 剪接和稳定性的转录共调节剂。这种多样化的功能有助于募集促进恶性肿瘤的转录因子。CARM1 介导的甲基化作用超出了其在转录控制中的既定作用，影响了一系列生物学过程，包括细胞周期、代谢、自噬、氧化还原平衡和炎症。通过操纵这些生理功能，CARM1 在肿瘤发生、转移和治疗耐药等关键过程中变得至关重要。因此，它成为治疗干预的一个可行靶点，并且可能成为特定癌症类型药物反应的生物标志物。本综述全面探讨了 CARM1 在癌症背景下的各种生理功能。此外，我们还讨论了用于癌症治疗的潜在 CARM1 靶向药物干预措施。
