突变双链DNA病毒逃避天然免疫控制

Escape of mutant double-stranded DNA virus from innate immune control.

作者信息

French Anthony R, Pingel Jeanette T, Wagner Markus, Bubic Ivan, Yang Liping, Kim Sungjin, Koszinowski Ulrich, Jonjic Stipan, Yokoyama Wayne M

机构信息

Division of Pediatric Rheumatology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.

出版信息

Immunity. 2004 Jun;20(6):747-56. doi: 10.1016/j.immuni.2004.05.006.

DOI:10.1016/j.immuni.2004.05.006

PMID:15189739

Abstract

As innate immune system components, natural killer (NK) cells respond rapidly to infections and effectively control replication of pathogens, including murine cytomegalovirus (MCMV), a double-stranded DNA beta-herpesvirus. In the absence of NK cell control, MCMV infection results in early mortality due to uncontrolled viral replication. However, here we show that even in the face of initial NK cell control, there is late recrudescence of disease and mortality in immunodeficient mice due to the outgrowth of MCMV mutants that escape recognition by innate NK cells. These data suggest that viral infections in certain clinical settings also may be due to viral escape from innate immunity.

摘要

作为先天性免疫系统的组成部分，自然杀伤（NK）细胞对感染反应迅速，并能有效控制病原体的复制，包括鼠巨细胞病毒（MCMV），一种双链DNAβ疱疹病毒。在缺乏NK细胞控制的情况下，MCMV感染会因病毒复制失控而导致早期死亡。然而，我们在此表明，即使面对最初的NK细胞控制，免疫缺陷小鼠仍会出现疾病晚期复发和死亡，这是由于逃脱先天性NK细胞识别的MCMV突变体的增殖所致。这些数据表明，在某些临床环境中的病毒感染也可能是由于病毒逃避先天性免疫所致。