[前列腺癌的Gleason组织学分级与血清PSA、原位PSA以及34βE12和P504S免疫组化表达的关系]
[Gleason histologic grading of prostate carcinoma in relation to serum PSA, PSA in situ and immunohistochemical expression of 34 beta E12 and P504S].
作者信息
Xiao Qin, Yin Honglin, Lu Zhenfeng, Meng Kui, Zhou Xiaojun
机构信息
Department of Pathology, Nanjing General Hospital of Nanjing Command, Nanjing, Jiangsu 210002, China.
出版信息
Zhonghua Nan Ke Xue. 2004 May;10(5):362-5.
OBJECTIVE
To study the Gleason histologic grading of prostate carcinoma in relation to the serum prostate-specific antigen (PSA) level and the PSA in situ of the tumor, and the immunohistochemical staining of basal cell-specific cytokertain(34 beta E12) and alpha-Methylacyl-CoA racemase(P504S) of the tumor.
METHODS
The serum PSA levels were measured in 40 cases of prostate carcinoma. The Gleason histologic grading was based on histopathologic examination of the tumors, and the immunohistochemical staining including PSA in situ (35 cases), 34 beta E12(12 cases) and P504S(10 cases) was examined.
RESULTS
The higher the Gleason histologic grading of prostate carcinoma, the higher the serum PSA level(P < 0.01), and the weaker the positive reaction of the immunohistochemical staining of PSA of the tumor(P < 0.05). And the tumor cells displayed positive reaction for P504S and negative for 34 beta E12.
CONCLUSION
The Gleason histologic grading of prostate carcinoma is positively related to the serum PSA level and negatively to PSA in situ of the tumor immunohistochemically. It is important to use immunohistochemical staining for 34 beta E12 and P504S in the pathologic diagnosis of prostate carcinoma.
目的
研究前列腺癌的Gleason组织学分级与血清前列腺特异性抗原（PSA）水平、肿瘤原位PSA以及肿瘤基底细胞特异性细胞角蛋白（34βE12）和α-甲基酰基辅酶A消旋酶（P504S）免疫组化染色的关系。
方法
测定40例前列腺癌患者的血清PSA水平。Gleason组织学分级基于肿瘤的组织病理学检查，并检测免疫组化染色，包括原位PSA（35例）、34βE12（12例）和P504S（10例）。
结果
前列腺癌的Gleason组织学分级越高，血清PSA水平越高（P<0.01），肿瘤PSA免疫组化染色阳性反应越弱（P<0.05）。肿瘤细胞P504S呈阳性反应，34βE12呈阴性反应。
结论
前列腺癌的Gleason组织学分级与血清PSA水平呈正相关，与肿瘤原位PSA免疫组化呈负相关。34βE12和P504S免疫组化染色在前列腺癌病理诊断中具有重要意义。
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