[¹²⁵I粒子植入近距离治疗局限性前列腺癌（附41例报告）]
[Brachytherapy of 125I implantation for localized prostate cancer (report of 41 cases)].
作者信息
Bai Qiang, Wang Yixin, Kaye Keith W
机构信息
Department of Urology, Affiliated Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China.
出版信息
Zhonghua Nan Ke Xue. 2004 May;10(5):371-3.
OBJECTIVE
To observe the effect of brachytherapy of 125I implantation on localized prostate cancer.
METHODS
Two-step technique was engaged in the implantation of 125I into the prostate for 41 localized prostate cancer patients. The prescription dosage of 125I was 160 Gy. TRUS and C-Arm X-ray were used for the confirmation of seeds location in the prostate.
RESULTS
Thirty-three patients were followed up for 3 to 4 years. Abnormal PSAs were found in 2 patients by positive biopsy. No patients died in this investigation. The early stage complications were urinary irritation symptoms that were severe within 6 months and disappeared after 1 year.
CONCLUSION
Brachytherapy of 125I implantation increases long-term tumor-free survival rate, with few long-term complications and some short-tern urinary stimulating symptoms.
目的
观察¹²⁵I粒子植入近距离治疗局限性前列腺癌的效果。
方法
采用两步法将¹²⁵I粒子植入41例局限性前列腺癌患者的前列腺内。¹²⁵I粒子的处方剂量为160 Gy。使用超声引导下经直肠超声（TRUS）和C型臂X射线来确认粒子在前列腺内的位置。
结果
33例患者随访3至4年。2例患者经活检阳性发现前列腺特异抗原（PSA）异常。本研究中无患者死亡。早期并发症为尿路刺激症状，6个月内较为严重，1年后消失。
结论
¹²⁵I粒子植入近距离治疗可提高长期无瘤生存率，长期并发症较少，有一些短期尿路刺激症状。
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