Wang Fu-li, Wang He, Qin Wei-jun, Wu Guo-jun, Zhang Geng, Li Kai-nan
Department of Urology, Fourth Military Medical University, Xi'an 710032, China.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2004 Mar;20(2):203-5.
To investigate the clinical significance of basic fibroblast growth factor (b-FGF) in human benign prostatic hyperplasia (BPH) and prostatic carcinoma (Pca).
b-FGF expressions were examined by RNA dot blot hybridization and immunohistochemical staining in prostate tissues from 40 normal cases (NP), 38 BPH and 36 Pca.
The expressions of b-FGF in BPH and Pca tissues were significantly higher than those in normal prostate tissues (P < 0.01). There was no significant correlation between the increased expression of b-FGF and the graduation of BPH, pathologic grading as well as clinical stages of Pca.
b-FGF may be secreted from BPH and Pca tissues themselves, which is closely involved in the genesis and development of BPH and Pca.
探讨碱性成纤维细胞生长因子（b-FGF）在人良性前列腺增生（BPH）和前列腺癌（Pca）中的临床意义。
采用RNA斑点杂交和免疫组化染色法检测40例正常前列腺组织（NP）、38例BPH组织及36例Pca组织中b-FGF的表达。
BPH和Pca组织中b-FGF的表达明显高于正常前列腺组织（P<0.01）。b-FGF表达增加与BPH的分级、Pca的病理分级及临床分期之间无显著相关性。
b-FGF可能由BPH和Pca组织自身分泌，其与BPH和Pca的发生发展密切相关。
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