Zhou Wen-Quan, Yin Hong-Lin, Zhang Zheng-Yu, Yi Xiao-Ming, Ge Jing-Ping, Zhou Shui-Gen, Cheng Wen, Wei Wu, Ma Hong-Qing, Ma Heng-Hui, Gao Jian-Ping
Department of Urology, Nanjing University School of Medicine/Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
Zhonghua Nan Ke Xue. 2008 Nov;14(11):987-92.
To investigate the expressions of VEGF in prostate cancer (PCa) and benign prostatic hyperplasia (BPH), their clinical significance and their relationship with that of ET-1.
A total of 44 specimens of PCa and 36 of BPH tissues were examined by the immunohistochemical Elivision plus method for the expressions of VEGF and ET-1. The intensity of staining for VEGF and ET-1 was assessed by light microscopy on a scale from "-" to "+ + +".
The rates of positive expression of VEGF were 69.4% in BPH and 80.9% in PCa, positive staining mostly in the cytoplasm of glandular epithelia and cancer cells, and strongly positive in all the stroma vascular endothelial cells. The staining intensity of VEGF was significantly higher in the PCa than in the BPH group (P < 0.05) , in the bone metastasis (BM) than in the non-BM group (P < 0.01), and in the lowly than in the highly and moderately differentiated PCa tissues (P < 0.01). The expression of VEGF was positively correlated with that of ET-1 ( r(s) = 0.780, P < 0.01).
VEGF is involved in the development, progression and metastasis of PCa. VEGF and ET-1 may play a joint role in its development and progression.
探讨血管内皮生长因子（VEGF）在前列腺癌（PCa）和良性前列腺增生（BPH）中的表达、其临床意义以及与内皮素-1（ET-1）表达的关系。
采用免疫组织化学Elivision plus法检测44例PCa组织标本和36例BPH组织标本中VEGF和ET-1的表达。通过光学显微镜对VEGF和ET-1的染色强度进行评估，范围为“-”至“+++”。
BPH中VEGF阳性表达率为69.4%，PCa中为80.9%，阳性染色主要位于腺上皮细胞和癌细胞的细胞质中，所有基质血管内皮细胞均呈强阳性。PCa组VEGF染色强度显著高于BPH组（P < 0.05），骨转移（BM）组高于非BM组（P < 0.01），低分化PCa组织低于高分化和中分化PCa组织（P < 0.01）。VEGF的表达与ET-1的表达呈正相关（r(s) = 0.780，P < 0.01）。
VEGF参与PCa的发生、发展和转移。VEGF和ET-1可能在其发生和发展中起共同作用。
