Hettiaratchy Shehan, Randolph Mark A, Petit François, Lee W P Andrew, Butler Peter E M
Division of Plastic Surgery/Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, WACC-453, Boston, MA 02114, USA.
Br J Plast Surg. 2004 Jul;57(5):381-91. doi: 10.1016/j.bjps.2004.02.012.
Composite tissue allotransplantation (CTA) holds great potential for reconstructive surgery. The recent hand transplants have made this a clinical reality. However, concerns about CTA have divided the medical community. The current transplants require life-long immunosuppression, which could place the recipients at risk of serious complications. In addition despite potent immunosuppression, chronic rejection may still negate any early favourable results. This article will outline the clinical experience of CTA, the major problems of the technique and the potential solutions to these problems.
复合组织异体移植（CTA）在重建外科手术中具有巨大潜力。近期的手部移植已使其成为临床现实。然而，对CTA的担忧使医学界产生了分歧。目前的移植需要终身免疫抑制，这可能使接受者面临严重并发症的风险。此外，尽管有强效免疫抑制，慢性排斥反应仍可能抵消任何早期的良好效果。本文将概述CTA的临床经验、该技术的主要问题以及针对这些问题的潜在解决方案。
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