Smith Vincent C, Zupancic John A F, McCormick Marie C, Croen Lisa A, Greene John, Escobar Gabriel J, Richardson Douglas K
Department of Neonatalogy, Beth Israel Deaconess Medical Center, and Harvard School of Public Health, Boston, Massachusetts 02115, USA.
J Pediatr. 2004 Jun;144(6):799-803. doi: 10.1016/j.jpeds.2004.03.026.
To describe rates and identify risk factors for rehospitalization during the first year of life among infants with bronchopulmonary dysplasia (BPD).
This was a retrospective cohort study of infants born at a gestational age (GA) <33 weeks, between 1995 and 1999. BPD was defined as requirement of supplemental oxygen and/or mechanical ventilation at 36 weeks' corrected GA. The outcome was rehospitalization for any reason before first birthday.
In the first year of life, 118 of 238 (49%) infants with BPD were rehospitalized, more than twice the rate of rehospitalization of the non-BPD population, which was 309 of 1359 (23%) (P=<.0001). No measured factor discriminated between those infants with BPD who were and were not rehospitalized, even when only rehospitalizations for respiratory diagnoses were considered.
Among premature infants, BPD substantially increases the risk of rehospitalization during the first year of life. Neither demographic nor physiologic factors predicted rehospitalization among the infants with BPD. Other factors, such as air quality of home environment, passive smoking exposure, respiratory syncytial virus prophylaxis, breast-feeding status, and/or parenting and primary care management styles, should be examined in future studies.
描述支气管肺发育不良（BPD）婴儿出生后第一年的再住院率，并确定其危险因素。
这是一项对1995年至1999年间出生时胎龄（GA）<33周的婴儿进行的回顾性队列研究。BPD定义为矫正胎龄36周时需要补充氧气和/或机械通气。观察指标为一岁前因任何原因再次住院。
在出生后第一年，238例BPD婴儿中有118例（49%）再次住院，这一比例是非BPD婴儿群体再住院率的两倍多，后者为1359例中的309例（23%）（P<0.0001）。即使仅考虑因呼吸系统诊断而再次住院的情况，也没有任何测量因素能够区分BPD患儿中是否再次住院。
在早产儿中，BPD显著增加了出生后第一年再次住院的风险。人口统计学和生理学因素均不能预测BPD患儿的再住院情况。未来研究应探讨其他因素，如家庭环境空气质量、被动吸烟暴露、呼吸道合胞病毒预防、母乳喂养状况和/或育儿及初级保健管理方式等。
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