Ramachandran Balasubramanian, Ravi Kasiappan, Narayanan Vengidusamy, Kandaswamy Muthusamy, Subramanian Sorimuthu
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, Tamil Nadu, India.
Clin Chim Acta. 2004 Jul;345(1-2):141-50. doi: 10.1016/j.cccn.2004.03.014.
Oxidative stress plays an important role in chronic complications of diabetes mellitus and hence the regulation of free radicals is essential in the treatment of diabetes. The protective effect of a new macrocyclic binuclear oxovanadium complex on antioxidant defense systems of liver and kidney was examined in streptozotocin-induced experimental diabetes in rats.
The levels of lipid peroxides, glutathione and the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase were assayed according to standard procedures in the liver and kidney of control and experimental groups of rats.
A significant decrease (p < 0.05) was observed in both the glutathione content and in the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase and a concomitant increase in the level of lipid peroxides in diabetic rats. The observed alterations in the antioxidant status of tissues reverted back to near normal levels after the oral administration of macrocyclic vanadium complex at a dose of 5 mg/kg body weight/rat/day for a period of 30 days.
The normoglycemic efficacy of the vanadium complex alleviates oxidative stress in streptozotocin-induced diabetes in rats.
氧化应激在糖尿病慢性并发症中起重要作用，因此自由基的调节在糖尿病治疗中至关重要。在链脲佐菌素诱导的大鼠实验性糖尿病中，研究了一种新型大环双核氧钒配合物对肝脏和肾脏抗氧化防御系统的保护作用。
按照标准程序测定对照组和实验组大鼠肝脏和肾脏中脂质过氧化物、谷胱甘肽的水平以及超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和谷胱甘肽-S-转移酶的活性。
糖尿病大鼠的谷胱甘肽含量以及超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶等抗氧化酶的活性均显著降低（p < 0.05），脂质过氧化物水平随之升高。口服剂量为5 mg/kg体重/大鼠/天的大环钒配合物30天后，观察到的组织抗氧化状态变化恢复到接近正常水平。
钒配合物的正常血糖疗效减轻了链脲佐菌素诱导的大鼠糖尿病中的氧化应激。
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