Qingling Fu, Xin Li, Chaowu Yan, Kangsheng Li, Xiaoxing Liao
Department of Microbiology and Immunology, Shantou University Medical College, Shantou, Guangdong 515031, P.R. China.
Neuroreport. 2004 Jun 28;15(9):1465-8. doi: 10.1097/01.wnr.0000130540.22012.77.
The correlation between nitric oxide (NO) levels in the cortices and brain lateralization was investigated via the paw preference test in which three groups of mice (left-pawed, ambidextrous and right pawed) were selected. Results showed that the right cortices had higher NO levels than the left cortices for both normal and lipopolysaccharide-treated mice. There were significant differences in NO levels in the right/left cortices depending on the behavioral lateralization as expressed by paw preference. Finally, individual levels of NO in the right/left cortices correlated well with individual paw preference scores. The relationship was parabolic. The results suggest a strong relationship between NO asymmetries as well as the direction and the intensity of behavioral lateralization.
通过爪子偏好测试研究了皮质中一氧化氮（NO）水平与大脑偏侧化之间的相关性，在该测试中选择了三组小鼠（左利手、双手并用和右利手）。结果表明，正常小鼠和脂多糖处理的小鼠，右侧皮质中的NO水平均高于左侧皮质。根据爪子偏好所表达的行为偏侧化，右侧/左侧皮质中的NO水平存在显著差异。最后，右侧/左侧皮质中NO的个体水平与个体爪子偏好得分密切相关。这种关系呈抛物线状。结果表明，NO不对称性与行为偏侧化的方向和强度之间存在密切关系。
