细菌类核的结构与分离

Structure and segregation of the bacterial nucleoid.

作者信息

Wu Ling Juan

机构信息

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

出版信息

Curr Opin Genet Dev. 2004 Apr;14(2):126-32. doi: 10.1016/j.gde.2004.01.006.

DOI:10.1016/j.gde.2004.01.006

PMID:15196458

Abstract

In bacteria, chromosome segregation and DNA replication occur concurrently and there is no clear equivalent of a eukaryote mitotic spindle. Chromosome segregation can be viewed as a two-step process. As the first step, the origin of replication regions are segregated actively, probably by a mechanism involving an as yet unidentified motor protein or proteins, and held in position. The second step is the separation and migration of the rest of the chromosome probably driven by forces generated from various cellular processes such as DNA replication, transcription and transertion.

摘要

在细菌中，染色体分离和DNA复制同时发生，并且没有与真核生物有丝分裂纺锤体明显等效的结构。染色体分离可视为一个两步过程。第一步，复制起始区域被主动分离，可能是通过一种涉及一种或多种尚未确定的运动蛋白的机制，并保持在特定位置。第二步是染色体其余部分的分离和迁移，这可能是由诸如DNA复制、转录和转座等各种细胞过程产生的力驱动的。