CD4CD25调节性T细胞中的关键分子FoxP3在成人T细胞白血病/淋巴瘤细胞中的表达。

Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells.

作者信息

Karube Kennosuke, Ohshima Koichi, Tsuchiya Takeshi, Yamaguchi Takahiro, Kawano Riko, Suzumiya Junji, Utsunomiya Atae, Harada Mine, Kikuchi Masahiro

机构信息

Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan.

出版信息

Br J Haematol. 2004 Jul;126(1):81-4. doi: 10.1111/j.1365-2141.2004.04999.x.

DOI:10.1111/j.1365-2141.2004.04999.x

PMID:15198736

Abstract

Adult T-cell leukaemia/lymphoma (ATLL) is an aggressive neoplastic disease that usually exhibits a CD4(+)CD25(+) phenotype. Regulatory T cells (Treg), which suppress T-cell effector function, are characterized by the co-expression of CD4 and CD25. We analysed the expression of forkhead/winged helix transcription factor (FoxP3), a specific marker that is important for the function of Treg, on ATLL cells from 17 patients (peripheral blood, n = 8; lymph node, n = 9). Real-time polymerase chain reaction and immunostaining detected FoxP3 expression in 10 ATLL cases, but was relatively down-regulated compared with Treg from normal subjects. These results indicate the association of ATLL and Treg.

摘要

成人T细胞白血病/淋巴瘤（ATLL）是一种侵袭性肿瘤疾病，通常表现为CD4(+)CD25(+)表型。调节性T细胞（Treg）可抑制T细胞效应功能，其特征为CD4和CD25的共表达。我们分析了叉头/翼状螺旋转录因子（FoxP3）在17例患者的ATLL细胞（外周血，n = 8；淋巴结，n = 9）中的表达，FoxP3是对Treg功能很重要的一种特异性标志物。实时聚合酶链反应和免疫染色在10例ATLL病例中检测到FoxP3表达，但与正常受试者的Treg相比相对下调。这些结果表明ATLL与Treg有关联。