Wu Zankai, Zhang Yanting, Gong Yiping, Hu Jin
Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Oncol. 2024 Nov 27;14:1448714. doi: 10.3389/fonc.2024.1448714. eCollection 2024.
Regulatory T (Treg) cells play a strategic role in maintaining immune homeostasis and their functions are closely linked to the development of different diseases, including cancer. This study aims to investigate the evolution patterns and popular research topics of Treg cells through bibliometric analysis.
The Web of Science Core Collection database was used to extract publications related to Treg cells, which were then subjected to bibliometric analysis and visualization through VOSviewer, CiteSpace, and R software.
Between 2003 and 2023, a total of 666 articles were published. China and the United States had the highest citation counts, with Fudan University, Shanghai Jiao Tong University, and Tarbiat Modares University being the leading research institutions. Beckhove Philipp from the German Cancer Research Center and the National Center for Tumor Diseases in Heidelberg, and Christophe from the Cancer Research Center of Lyon, were the most prolific authors. Sakaguchi Shimon from the Immunology Frontier Research Center at Osaka University was the most cited author. "Frontiers in Immunology" published the most articles, while "Journal of Immunology" received the highest co-citations. Key terms in Treg research include immunotherapy, tumor microenvironment, prognosis, immunosuppression, and PD-L1. Among these, immunotherapy, prognosis, PD-L1, and immunosuppression have emerged as focal points of research in recent years.
With active collaboration worldwide, research on Treg cells is rapidly advancing. Focusing on Treg cells as a potential target for cancer treatment shows great promise for future research, especially in terms of practical applications. This could offer valuable direction and fresh perspectives for further exploration of Treg cells in the medical field.
调节性T（Treg）细胞在维持免疫稳态中发挥着关键作用，其功能与包括癌症在内的多种疾病的发展密切相关。本研究旨在通过文献计量分析探讨Treg细胞的演变模式和热门研究主题。
利用科学网核心合集数据库提取与Treg细胞相关的出版物，然后通过VOSviewer、CiteSpace和R软件进行文献计量分析和可视化。
2003年至2023年期间，共发表了666篇文章。中国和美国的被引频次最高，复旦大学、上海交通大学和德黑兰塔比阿特莫达雷斯大学是主要研究机构。德国癌症研究中心和海德堡国家肿瘤疾病中心的贝克霍夫·菲利普以及里昂癌症研究中心的克里斯托夫是发文量最多的作者。大阪大学免疫前沿研究中心的坂口志免是被引频次最高的作者。《免疫学前沿》发表的文章最多，而《免疫学杂志》获得的共被引频次最高。Treg研究的关键词包括免疫治疗、肿瘤微环境、预后、免疫抑制和程序性死亡受体配体1（PD-L1）。其中，免疫治疗、预后、PD-L1和免疫抑制已成为近年来的研究热点。
随着全球范围内的积极合作，Treg细胞的研究正在迅速推进。将Treg细胞作为癌症治疗的潜在靶点进行研究，对未来研究具有广阔前景，尤其是在实际应用方面。这可为医学领域进一步探索Treg细胞提供有价值的方向和新的视角。
