Wang Xue-mei, Fu Hong, Liu Geng-xin
First Hospital, Peking University, Beijing 100034.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 May;24(5):392-5.
To observe the clinical efficacy and safety of modified Wuzi Yanzong Granule (MWYG) in treating mild cognitive impairment (MCI), and to explore its mechanism.
Forty-four MCI patients were selected referring to the international recognized Peterson's criteria and randomly divided into two groups, the treated group treated with MWYG and the control group treated with Ginkgo leaf extraction, with the course of 3 months for both groups. Changes of memorial quotient (MQ), superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, mitochondrial DNA (mtDNA) deletion rate and acetylcholinesterase (AchE) before and after treatment were observed.
After treatment, levels of MQ, serum SOD activity increased and serum MDA content, mtDNA deletion rate and AchE decreased in both groups (P < 0.01), but the difference between the two groups was insignificant. No adverse reaction was found in two groups.
Both MWYG and Ginkgo leaf capsule can effectively improve the memorial function of patients with MCI, the therapeutic mechanism is possibly related with the actions in reducing AchE activity, improving free radical metabolism, and alleviating mitochondrial DNA oxidation damage.
观察加味五子衍宗颗粒（MWYG）治疗轻度认知功能障碍（MCI）的临床疗效及安全性，并探讨其作用机制。
参照国际公认的彼得森标准选取44例MCI患者，随机分为两组，治疗组服用MWYG，对照组服用银杏叶提取物，两组疗程均为3个月。观察治疗前后记忆商（MQ）、超氧化物歧化酶（SOD）活性、丙二醛（MDA）含量、线粒体DNA（mtDNA）缺失率及乙酰胆碱酯酶（AchE）的变化。
治疗后，两组患者的MQ水平、血清SOD活性升高，血清MDA含量、mtDNA缺失率及AchE降低（P < 0.01），但两组间差异无统计学意义。两组均未发现不良反应。
MWYG和银杏叶胶囊均可有效改善MCI患者的记忆功能，其治疗机制可能与降低AchE活性、改善自由基代谢及减轻线粒体DNA氧化损伤有关。
