Jin Zhong-da, Wang Shou-chuan, Sun Yi-qiu
First Hospital Affiliated to Nanjing TCM University, Nanjing 210029.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 Dec;23(12):905-7.
To explore the effect and mechanism of Danshao Granule (DSG) in treating Henoch-Schonlein purpura nephritis (HSPN) in children.
The 63 patients with HSPN were randomly divided into two groups. The 32 patients in the treated group were treated with DSG and the 31 patients in the control group were treated with Tripterygium polyglycosides tablet and composite Salviae tablet. The therapeutic course for both groups was one month. The skin purpura, macroscopic hematuria, hypertension and edema subsidence time, 24 hrs urinary protein content, serum levels of immunoglobulins (IgA, IgG, IgM), superoxide dismutase (SOD) activity and malonyldialdehyde (MDA) content were observed before and after treatment.
Therapeutic effect in the treated group was better than that in the control group in curing skin purpura and macroscopic hematuria (P < 0.05). The 24 hrs urinary protein content and serum levels of IgA, SOD and MDA were improved after treatment in both groups significantly (P < 0.01). However, the improvement of 24 hrs urinary protein, serum SOD and MDA in the treated group was more significant than that in the control group respectively (P < 0.05).
DSG can alleviate the injury of free radicals in organism, so it is an ideal remedy for treatment of HSPN.
探讨丹芍颗粒（DSG）治疗小儿过敏性紫癜性肾炎（HSPN）的疗效及作用机制。
将63例HSPN患儿随机分为两组。治疗组32例，给予DSG治疗；对照组31例，给予雷公藤多苷片和复方丹参片治疗。两组疗程均为1个月。观察治疗前后皮肤紫癜、肉眼血尿、高血压及水肿消退时间、24小时尿蛋白含量、血清免疫球蛋白（IgA、IgG、IgM）水平、超氧化物歧化酶（SOD）活性及丙二醛（MDA）含量。
治疗组在治愈皮肤紫癜和肉眼血尿方面的疗效优于对照组（P<0.05）。两组治疗后24小时尿蛋白含量及血清IgA、SOD和MDA水平均明显改善（P<0.01）。然而，治疗组24小时尿蛋白、血清SOD和MDA的改善分别比对照组更显著（P<0.05）。
DSG可减轻机体自由基损伤，是治疗HSPN的理想药物。
