Colak Tahsin, Ipek Turgut, Urkaya Namik, Kanik Arzu, Dirlik Musa
Mersin University Medical Faculty, Department of General Surgery, Mersin, Turkey.
Eur J Surg Suppl. 2003 Jul(588):18-22.
To compare a systemic transdermal therapeutic system with local application of glyceryl trinitrate ointment in the treatment of anal fissure.
Prospective, multicentre, randomised trial.
Three teaching hospitals, Turkey.
89 outpatients with chronic anal fissure were randomly assigned to be treated with either transdermal (n = 52) or 0.2% glyceryl trinitrate ointment (n = 37).
The patients were assessed at the sixth and the twelfth week after initial evaluation by physical examination, anoscopy, and anal manometry.
Changes in the maximal anal resting pressure, healing rate.
Anal fissure was completely healed in 38 (73%) and 24 (64%) of the patients after 6 weeks and 48 (81%) and 27 (79%) of the patients in transdermal group and ointment group, respectively. Maximal anal resting pressure was reduced by 24% and 21% in transdermal and ointment groups, respectively.
Systemic transdermal application of glyceryl trinitrate gave a satisfactory healing rate, which was comparable to that of local application of ointment.
比较硝酸甘油全身透皮治疗系统与局部应用硝酸甘油软膏治疗肛裂的效果。
前瞻性、多中心、随机试验。
土耳其的三家教学医院。
89例慢性肛裂门诊患者被随机分为两组，分别接受透皮治疗（n = 52）或0.2%硝酸甘油软膏治疗（n = 37）。
在初次评估后的第6周和第12周，通过体格检查、肛门镜检查和肛门测压对患者进行评估。
最大肛门静息压的变化、愈合率。
透皮组和软膏组分别有38例（73%）和24例（64%）患者在6周后肛裂完全愈合，48例（81%）和27例（79%）患者在12周后肛裂完全愈合。透皮组和软膏组的最大肛门静息压分别降低了24%和21%。
硝酸甘油全身透皮应用的愈合率令人满意，与局部应用软膏的效果相当。
