Ward Donald T
School of Biological Sciences, University of Manchester, G38 Stopford Building, Oxford Road, Manchester M13 9PT, UK.
Cell Calcium. 2004 Mar;35(3):217-28. doi: 10.1016/j.ceca.2003.10.017.
As a G protein-coupled receptor (GPCR), the extracellular calcium-sensing receptor (CaR) responds to changes in extracellular free calcium concentration by inducing intracellular signalling. These CaR-induced signals then specifically modulate cellular functions such as parathyroid hormone secretion from the parathyroid glands and calcium reabsorption in the kidney and thus to understand how the CaR functions one must understand how it signals. CaR-induced signalling involves intracellular Ca2+ mobilisation/oscillations as well as the activation of various phospholipases and protein kinases and the suppression of cAMP formation. This review will detail the intracellular pathways by which the CaR is believed to elicit its physiological functions and summarises the evidence for cell- and agonist-specific differential signalling.
作为一种G蛋白偶联受体（GPCR），细胞外钙敏感受体（CaR）通过诱导细胞内信号传导来响应细胞外游离钙浓度的变化。这些由CaR诱导的信号随后特异性地调节细胞功能，如甲状旁腺分泌甲状旁腺激素以及肾脏中的钙重吸收，因此，要了解CaR的功能，就必须了解其信号传导方式。CaR诱导的信号传导涉及细胞内Ca2+的动员/振荡以及各种磷脂酶和蛋白激酶的激活，以及cAMP形成的抑制。本综述将详细阐述CaR被认为引发其生理功能的细胞内途径，并总结细胞和激动剂特异性差异信号传导的证据。
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