钙敏感受体对肾脏矿物质离子转运的调节
Calcium-sensing receptor regulation of renal mineral ion transport.
作者信息
Ba Jianming, Friedman Peter A
机构信息
Department of Pharmacology, University of Pittsburgh School of Medicine, E-1347 Biomedical Science Tower, Pittsburgh, PA 15261, USA.
出版信息
Cell Calcium. 2004 Mar;35(3):229-37. doi: 10.1016/j.ceca.2003.10.016.
Extracellular calcium has long been known to affect the rate and magnitude of renal calcium and phosphate recovery. In this review, we consider some of these findings in light of our present understanding of the tubular localization of the calcium-sensing receptor (CaSR). Experiments directly implicating the CaSR in regulating calcium and phosphate transport are described. These results point to an important role of the CaSR in regulating PTH-dependent calcium absorption by cortical thick ascending limbs and on PTH-sensitive proximal tubule phosphate transport. Possible avenues for further investigation are suggested.
长期以来，人们一直知道细胞外钙会影响肾脏对钙和磷的重吸收率及重吸收量。在这篇综述中，我们根据目前对钙敏感受体（CaSR）肾小管定位的理解，对其中一些研究结果进行了探讨。文中描述了直接表明CaSR参与调节钙和磷转运的实验。这些结果表明，CaSR在调节皮质厚升支对甲状旁腺激素（PTH）依赖的钙吸收以及PTH敏感的近端小管磷转运方面具有重要作用。文中还提出了进一步研究的可能途径。
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