Chohan Zahid H, Pervez Humayun, Khan Khalid Mohammed, Rauf A, Supuran Claudiu T
Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan.
J Enzyme Inhib Med Chem. 2004 Feb;19(1):51-6. doi: 10.1080/14756360310001623318.
A method is described for the preparation of novel cephalexin-derived furanyl-, thiophenyl-, pyrrolyl-, salicylyl- and pyridyl-containing compounds showing potent antibacterial activity. The binding of these newly synthesized antibacterial agents with metal ions such as cobalt(II), copper(II), nickel(II) and zinc(II) has been studied and their inhibitory properties against various bacterial species such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae are also reported. These results suggest that metal ions to possess an important role in the designing of metal-based antibacterials and that such complexes are more effective against infectious diseases compared to the uncomplexed drugs.
描述了一种制备具有强效抗菌活性的新型头孢氨苄衍生的含呋喃基、噻吩基、吡咯基、水杨基和吡啶基化合物的方法。研究了这些新合成的抗菌剂与钴(II)、铜(II)、镍(II)和锌(II)等金属离子的结合情况,并报告了它们对大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌和肺炎克雷伯菌等各种细菌的抑制特性。这些结果表明,金属离子在基于金属的抗菌剂设计中具有重要作用,并且与未络合的药物相比,此类络合物对传染病更有效。