Chohan Zahid H, Pervez Humayun, Khan Khalid M, Rauf A, Maharvi Ghulam M, Supuran Claudiu T
Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan.
J Enzyme Inhib Med Chem. 2004 Feb;19(1):85-90. doi: 10.1080/14756360310001650183.
Some novel cephalexin-derived furanyl, thiophenyl, pyrrolyl, salicylyl and pyridyl Schiff's bases and their cobalt (II), copper (II), nickel (II) and zinc (II) complexes have been synthesized and studied for their antifungal properties against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glaberata. The presence of metal ions in the investigated Schiff's base complexes reported here lead to significant antifungal activity, whereas the parent ligands were generally less active.
一些新型头孢氨苄衍生的呋喃基、噻吩基、吡咯基、水杨基和吡啶基席夫碱及其钴（II）、铜（II）、镍（II）和锌（II）配合物已被合成，并研究了它们对长须毛癣菌、白色念珠菌、黄曲霉、犬小孢子菌、茄病镰刀菌和光滑念珠菌的抗真菌特性。本文报道的所研究席夫碱配合物中金属离子的存在导致显著的抗真菌活性，而母体配体通常活性较低。
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