Mordini Emilio
Secretary of the Bioethical Commission of the National Research Council Centre for Science, Society and Citizenship, Rome, Italy.
Pharmacol Res. 2004 Apr;49(4):375-9. doi: 10.1016/j.phrs.2003.04.001.
Pharmacogenetics offers the prospect of an era of safer and more effective drugs, as well as more individualized use of drug therapies. The effect of human genetic variance on responses to therapy will influence drug-development clinical trials and the use of products in clinical practice. It also promises to raise new ethical challenges, in particular in the fields of research and therapy. Last but not least, pharmacogenetics is likely to fulfil the old dream of an individualised medicine, but in a totally unexpected way.
药物遗传学为一个更安全、更有效的药物时代以及药物治疗的更个体化应用带来了希望。人类基因变异对治疗反应的影响将影响药物研发临床试验以及临床实践中产品的使用。它也可能带来新的伦理挑战,尤其是在研究和治疗领域。最后但同样重要的是,药物遗传学可能会以一种完全意想不到的方式实现个体化医疗的古老梦想。