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药物设计的种族化:药物基因组学对健康差异的影响。

Racializing drug design: implications of pharmacogenomics for health disparities.

作者信息

Lee Sandra Soo-Jin

机构信息

Stanford Center for Biomedical Ethics, Stanford University, Palo Alto, CA 94304, USA.

出版信息

Am J Public Health. 2005 Dec;95(12):2133-8. doi: 10.2105/AJPH.2005.068676. Epub 2005 Oct 27.

Abstract

Current practices of using "race" in pharmacogenomics research demands consideration of the ethical and social implications for understandings of group difference and for efforts to eliminate health disparities. This discussion focuses on an "infrastructure of racialization" created by current trajectories of research on genetic differences among racially identified groups, the use of race as a proxy for risk in clinical practice, and increasing interest in new market niches by the pharmaceutical industry. The confluence of these factors has resulted in the conflation of genes, disease, and race. I argue that public investment in pharmacogenomics requires careful consideration of current inequities in health status and social and ethical concerns over reifying race and issues of distributive justice.

摘要

药物基因组学研究中当前使用“种族”的做法,需要我们考虑其对理解群体差异以及消除健康差距努力所产生的伦理和社会影响。本讨论聚焦于由当前针对按种族划分群体间基因差异的研究轨迹所构建的“种族化基础设施”、在临床实践中使用种族作为风险替代指标,以及制药行业对新市场细分领域兴趣的不断增加。这些因素的交汇导致了基因、疾病和种族的混淆。我认为,对药物基因组学的公共投资需要仔细考虑当前健康状况的不平等,以及在将种族具体化和分配正义问题上的社会和伦理关切。

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