丝氨酰 - 组氨酸及相关二肽对DNA切割活性的分子模拟

Molecular modeling on DNA cleavage activity of seryl-histidine and related dipeptide.

作者信息

Sun Ming, Ma Yuan, Ji Sanhao, Liu Huanai, Zhao Yufen

机构信息

The Key Laboratory of Bioorganic Phosphorous Chemistry, Ministry of Education, China, Department of Chemistry, Tsinghua University, Beijing 100084, China.

出版信息

Bioorg Med Chem Lett. 2004 Jul 16;14(14):3711-4. doi: 10.1016/j.bmcl.2004.05.008.

DOI:10.1016/j.bmcl.2004.05.008

PMID:15203148

Abstract

Molecular interaction between seryl-histidine (or seryl-histidine related dipeptides) and DNA model molecule 5'-TpTpdC-3' was studied by a molecular docking procedure. The key structural features of DNA cleaving activity were investigated.

摘要

通过分子对接程序研究了丝氨酰 - 组氨酸（或丝氨酰 - 组氨酸相关二肽）与DNA模型分子5'-TpTpdC-3'之间的分子相互作用。研究了DNA切割活性的关键结构特征。