通过偶氮苯衍生物连接的铜（II）结合二肽的空间取向和DNA切割活性的光控

Photocontrol of spatial orientation and DNA cleavage activity of copper(II)-bound dipeptides linked by an azobenzene derivative.

作者信息

Prakash Halan, Shodai Akemi, Yasui Hiroyuki, Sakurai Hiromu, Hirota Shun

机构信息

Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara, Japan.

出版信息

Inorg Chem. 2008 Jun 16;47(12):5045-7. doi: 10.1021/ic8007443. Epub 2008 May 14.

DOI:10.1021/ic8007443

PMID:18476687

Abstract

Copper(II) ion-bound CysGly dipeptides linked by an azobenzene derivative were photoisomerized between the trans and cis forms. The two copper(II) ion centers were positioned close to each other in the cis form, whereas they were far away from each other in the trans form. The copper complex in the cis form exhibited DNA cleavage activity, whereas the activity in the trans form was negligible. The DNA cleavage activity of the cis form is attributed to the cooperation of the closely located copper(II) centers. The present results show the photocontrol of the cooperation of metal ions for DNA cleavage.

摘要

通过偶氮苯衍生物连接的铜（II）离子结合的半胱氨酰甘氨酸二肽在反式和顺式之间进行光异构化。两个铜（II）离子中心在顺式中彼此靠近，而在反式中彼此远离。顺式的铜配合物表现出DNA切割活性，而反式中的活性可忽略不计。顺式的DNA切割活性归因于紧密定位的铜（II）中心的协同作用。目前的结果表明了金属离子协同作用用于DNA切割的光控。