“超低”剂量纳曲酮与吗啡在成年及幼年雄性和雌性大鼠中的相互作用。
Interactions of "ultra-low" doses of naltrexone and morphine in mature and young male and female rats.
作者信息
Hamann Scott R, Malik Hammad, Sloan Jewell W, Wala Elzbieta P
机构信息
Department of Anesthesiology, College of Medicine, University of Kentucky, Lexington, KY 40536-0293, USA.
出版信息
Recept Channels. 2004;10(2):73-81. doi: 10.1080/10606820490464334.
Sex and age influence morphine analgesia in humans and animals. Mature rats show greater morphine analgesia in males than in females. Ultra-low doses of naltrexone enhance morphine analgesia. In mature rats (18-22 weeks), naltrexone (0.002-2.0 mg/kg)-morphine (2 mg/kg) cotreatment enhanced morphine analgesia in females, an effect inversely related to naltrexone dose. Conversely, in mature male rats, naltrexone tended to decrease morphine analgesia with increasing dose. In young rats (8-10 weeks), morphine analgesia was unrelated to sex and in both sexes the naltrexone-morphine interaction was negligible. These data show that dose, age, and sex alter the naltrexone-morphine interaction in rats.
性别和年龄会影响人类和动物对吗啡的镇痛反应。成年大鼠中，雄性比雌性对吗啡的镇痛效果更明显。超低剂量的纳曲酮可增强吗啡的镇痛作用。在成年大鼠（18 - 22周）中，纳曲酮（0.002 - 2.0毫克/千克）与吗啡（2毫克/千克）联合治疗可增强雌性大鼠的吗啡镇痛作用，且该作用与纳曲酮剂量呈负相关。相反，在成年雄性大鼠中，随着纳曲酮剂量增加，其倾向于降低吗啡的镇痛作用。在幼鼠（8 - 10周）中，吗啡镇痛作用与性别无关，且在两性中纳曲酮与吗啡的相互作用可忽略不计。这些数据表明，剂量、年龄和性别会改变大鼠体内纳曲酮与吗啡的相互作用。
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