Singh A D, Rennie I G, Kivela T, Seregard S, Grossniklaus H
Department of Ophthalmic Oncology, Cole Eye Institute (i3-129), Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Br J Ophthalmol. 2004 Jul;88(7):962-7. doi: 10.1136/bjo.2003.029058.
It is now 25 years since the publication of the landmark article by Zimmerman, McLean, and Foster, in which they cast doubts on the benefit of enucleation, which was the prevailing management of choroidal melanoma at that time. Over the past 25 years several advances have been made in the management of uveal melanoma. Research in the pathobiology of cancer metastasis in general and uveal melanoma in particular has also provided new insights. In this review, the Zimmerman-McLean-Foster hypothesis is explored in the light of current clinical, epidemiological, statistical, and experimental evidence.
自齐默尔曼、麦克莱恩和福斯特发表具有里程碑意义的文章至今已有25年,在那篇文章中,他们对眼球摘除术的益处提出了质疑,而眼球摘除术是当时脉络膜黑色素瘤的主流治疗方法。在过去的25年里,葡萄膜黑色素瘤的治疗取得了多项进展。对癌症转移,尤其是葡萄膜黑色素瘤的病理生物学研究也提供了新的见解。在这篇综述中,我们根据当前的临床、流行病学、统计学和实验证据探讨了齐默尔曼-麦克莱恩-福斯特假说。