纽约市出现携带A类碳青霉烯水解酶KPC - 2和抑制剂耐药性TEM - 30β-内酰胺酶的耐碳青霉烯克雷伯菌属细菌。
Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 beta-lactamases in New York City.
作者信息
Bradford Patricia A, Bratu Simona, Urban Carl, Visalli Melissa, Mariano Noriel, Landman David, Rahal James J, Brooks Steven, Cebular Sanda, Quale John
机构信息
Wyeth Research, Pearl River, NY, USA.
出版信息
Clin Infect Dis. 2004 Jul 1;39(1):55-60. doi: 10.1086/421495. Epub 2004 Jun 14.
Nineteen isolates of carbapenem-resistant Klebsiella species were recovered from 7 hospitals in New York City. Most K. pneumoniae belonged to a single ribotype. Nucleotide sequencing identified KPC-2, a carbapenem-hydrolyzing beta -lactamase. In 3 strains, TEM-30, an inhibitor-resistant beta -lactamase, was detected. Carbapenem-resistant Klebsiella species possessing KPC-2 are endemic in New York City. This study documents the identification of an inhibitor-resistant TEM beta -lactamase in the United States.
从纽约市的7家医院分离出19株耐碳青霉烯类克雷伯菌属菌株。大多数肺炎克雷伯菌属于单一核糖体分型。核苷酸测序鉴定出KPC-2，一种碳青霉烯水解β-内酰胺酶。在3株菌株中检测到TEM-30，一种耐抑制剂β-内酰胺酶。携带KPC-2的耐碳青霉烯类克雷伯菌属菌株在纽约市呈地方性流行。本研究记录了在美国鉴定出一种耐抑制剂的TEMβ-内酰胺酶。
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