Cabrera Adriana, Mason Emily, Mullins Liam P, Sadarangani Manish
Experimental Medicine Program, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
NPJ Antimicrob Resist. 2025 Apr 28;3(1):34. doi: 10.1038/s44259-025-00100-8.
Antimicrobial-resistant Enterobacteriaceae are increasingly a clinical challenge. In particular, extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae threaten public health. Vaccination presents a long-term strategy to reduce both drug-susceptible and resistant infections while maintaining current clinical therapies. The review aims to emphasize the need for vaccines targeting extraintestinal pathogenic E. coli and K. pneumoniae by providing an overview of disease burden, antimicrobial resistance, therapeutics, and vaccine development.
耐抗菌药物的肠杆菌科细菌日益成为临床挑战。特别是，肠外致病性大肠杆菌和肺炎克雷伯菌威胁着公众健康。接种疫苗是一种长期战略，可在维持现有临床治疗方法的同时减少药物敏感和耐药感染。本综述旨在通过概述疾病负担、抗菌药物耐药性、治疗方法和疫苗研发情况，强调针对肠外致病性大肠杆菌和肺炎克雷伯菌的疫苗的必要性。
