Torii Akira, Toda Gotaro
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-0003.
Intern Med. 2004 May;43(5):353-9. doi: 10.2169/internalmedicine.43.353.
Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders. The prevalence rate is 10-20% and women have a higher prevalence. IBS adversely affects quality of life and is associated with health care use and costs. IBS comprises a group of functional bowel disorders in which abdominal discomfort or pain is associated with defecation or a change in bowel habit, and with features of disordered defecation. The consensus definition and criteria for IBS have been formalized in the "Rome II criteria". Food, psychiatric disorders, and gastroenteritis are risk factors for developing IBS. The mechanism in IBS involves biopsychosocial disorders; psychosocial factors, altered motility, and heightened sensory function. Brain-gut interaction is the most important in understanding the pathophysiology of IBS. Effective management requires an effective physician-patient relationship. Dietary treatment, lifestyle therapy, behavioral therapy, and pharmacologic therapy play a major role in treating IBS. Calcium polycarbophil can benefit IBS patients with constipation or alternating diarrhea and constipation.
肠易激综合征(IBS)是最常见的功能性胃肠疾病之一。患病率为10%-20%,女性患病率更高。IBS对生活质量有不利影响,并与医疗保健的使用和费用相关。IBS包括一组功能性肠病,其中腹部不适或疼痛与排便或排便习惯改变以及排便紊乱特征相关。IBS的共识定义和标准已在“罗马II标准”中正式确定。食物、精神障碍和肠胃炎是发生IBS的危险因素。IBS中的机制涉及生物心理社会障碍;心理社会因素、运动改变和感觉功能增强。脑-肠相互作用在理解IBS的病理生理学中最为重要。有效的管理需要有效的医患关系。饮食治疗、生活方式疗法、行为疗法和药物疗法在治疗IBS中起主要作用。聚卡波非钙可使便秘型或腹泻便秘交替型IBS患者受益。