Ruigómez Ana, Wallander Mari-Ann, Johansson Saga, Rodríguez Luis Alberto García
Spanish Centre for Pharmacoepidemiological Research (CEIFE), Almirante 28, 2 masculine, 28004 Madrid, Spain.
Dig Dis Sci. 2009 May;54(5):1079-86. doi: 10.1007/s10620-008-0462-0. Epub 2008 Aug 22.
Population-based studies have shown that gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) coexist more commonly than expected by chance. We aimed to investigate the relationship between GERD and IBS in primary care. The General Practice Research Database was used to identify patients with a first diagnosis of GERD (n=6,421) or IBS (n=2,932). Patients were followed up for 12 months after diagnosis to investigate the incidence of IBS among GERD patients and GERD among IBS patients. The relative risk (RR) of developing IBS was 3.5 (95% CI: 2.3-5.4) in the GERD cohort compared with the comparison cohort. The RR of developing GERD was 2.8 (95% CI: 1.7-4.9) in the IBS cohort compared with the comparison cohort. A first diagnosis of either IBS or GERD significantly increases the risk of a subsequent diagnosis of the other condition.
基于人群的研究表明，胃食管反流病（GERD）和肠易激综合征（IBS）的共存比偶然预期的更为常见。我们旨在研究基层医疗中GERD与IBS之间的关系。利用全科医疗研究数据库识别首次诊断为GERD（n = 6421）或IBS（n = 2932）的患者。患者在诊断后随访12个月，以调查GERD患者中IBS的发病率以及IBS患者中GERD的发病率。与对照队列相比，GERD队列中发生IBS的相对风险（RR）为3.5（95%可信区间：2.3 - 5.4）。与对照队列相比，IBS队列中发生GERD的RR为2.8（95%可信区间：1.7 - 4.9）。IBS或GERD的首次诊断显著增加了随后诊断出另一种疾病的风险。
