外用他克莫司（FK506）治疗与克罗恩病相关的顽固性造口周围坏疽性脓皮病：两例报告
Topical tacrolimus (FK506) in the treatment of recalcitrant parastomal pyoderma gangrenosum associated with Crohn's disease: report of two cases.
作者信息
Khurrum Baig M, Marquez H, Nogueras J J, Weiss E G, Wexner S D
机构信息
Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, Florida 33331, USA.
出版信息
Colorectal Dis. 2004 Jul;6(4):250-3. doi: 10.1111/j.1463-1318.2004.00607.x.
INTRODUCTION
Pyoderma gangrenosum is a rare idiopathic skin disorder associated with other diseases, including inflammatory bowel disease. The commonest site is the skin, but sometimes it can occur in the parastomal region. Most of these cases respond to treatment with systemic corticosteroids and cyclosporin or local Kenalog injections.
METHODS
The following are two cases of parastomal pyoderma in patients not responding to the standard measures. These patients were treated with topical tacrolimus.
RESULTS
These patients showed dramatic improvement in one week with complete resolution and re-epithelialization of skin within two weeks.
CONCLUSION
Pyoderma gangrenosum is a difficult problem to manage and its early resolution is important. In these two reported cases, the improvement was dramatic, therefore topical tacrolimus should be considered early in the management.
引言
坏疽性脓皮病是一种罕见的特发性皮肤疾病，与包括炎症性肠病在内的其他疾病相关。最常见的发病部位是皮肤，但有时也可发生在造口旁区域。这些病例大多对全身用皮质类固醇和环孢素治疗或局部注射曲安奈德有反应。
方法
以下是两例造口旁坏疽性脓皮病患者，对标准治疗措施无效。这些患者接受了外用他克莫司治疗。
结果
这些患者在一周内病情显著改善，两周内皮肤完全愈合且重新上皮化。
结论
坏疽性脓皮病是一个难以处理的问题，早期解决很重要。在这两例报告的病例中，改善非常显著，因此在治疗早期应考虑外用他克莫司。
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