CD1d 限制性自然杀伤 T 细胞在疾病中的免疫调节作用。

The immunoregulatory role of CD1d-restricted natural killer T cells in disease.

作者信息

van der Vliet Hans J J, Molling Johan W, von Blomberg B Mary E, Nishi Nobusuke, Kölgen Wendy, van den Eertwegh Alfons J M, Pinedo Herbert M, Giaccone Giuseppe, Scheper Rik J

机构信息

The Departments of Pathology, Vrije Universiteit Medisch Centrum, Amsterdam, The Netherlands.

出版信息

Clin Immunol. 2004 Jul;112(1):8-23. doi: 10.1016/j.clim.2004.03.003.

DOI:10.1016/j.clim.2004.03.003

PMID:15207777

Abstract

Natural killer T (NKT) cells constitute a T cell subpopulation that shares several characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor (TCR) repertoire, recognize glycolipid antigen in the context of the monomorphic CD1d antigen-presenting molecule, and have the unique capacity to rapidly produce large amounts of both T helper (Th) 1 and Th2 cytokines. Important roles of NKT cells have now been demonstrated in the regulation of autoimmune, allergic, antimicrobial, and antitumor immune responses. Here, we review the immunoregulatory role of NKT cells in disease and discuss NKT cell based immunotherapeutic strategies.

摘要

自然杀伤T（NKT）细胞是一类与自然杀伤（NK）细胞具有若干共同特征的T细胞亚群。NKT细胞的特点是T细胞抗原受体（TCR）库狭窄，在单态性CD1d抗原呈递分子的背景下识别糖脂抗原，并具有快速产生大量辅助性T（Th）1和Th2细胞因子的独特能力。目前已证明NKT细胞在自身免疫、过敏、抗菌和抗肿瘤免疫反应的调节中发挥重要作用。在此，我们综述NKT细胞在疾病中的免疫调节作用，并讨论基于NKT细胞的免疫治疗策略。