Foxp3：调节性T细胞发育和功能的关键调节因子。
Foxp3: a critical regulator of the development and function of regulatory T cells.
作者信息
Hori Shohei, Sakaguchi Shimon
机构信息
Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
出版信息
Microbes Infect. 2004 Jul;6(8):745-51. doi: 10.1016/j.micinf.2004.02.020.
Regulatory T cells are capable of suppressing deleterious immune responses against self- or non-self-antigens. Their essential role in tolerance and immune regulation has been illustrated by recent findings that mutations in the Foxp3 gene leads to the defective development of regulatory T cells and the emergence of a fatal autoimmune, inflammatory and allergic disease. This review discusses the critical role for this transcription factor in the development and function of regulatory T cells.
调节性T细胞能够抑制针对自身或非自身抗原的有害免疫反应。最近的研究发现表明，Foxp3基因的突变会导致调节性T细胞发育缺陷，并引发致命的自身免疫性、炎症性和过敏性疾病，这说明了它们在耐受性和免疫调节中的重要作用。本综述讨论了这种转录因子在调节性T细胞的发育和功能中的关键作用。
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