从芽的视角看视网膜母细胞瘤。（注：不太确定RB准确所指，如果结合医学语境可能是视网膜母细胞瘤Retinoblastoma ，具体需根据更多背景信息确定）

RB from a bud's eye view.

作者信息

Schaefer Jonathan B, Breeden Linda L

机构信息

Fred Hutchinson Cancer Research Center, Basic Sciences Division, 1100 Fairview Avenue North, Seattle, Washington 98109, USA.

出版信息

Cell. 2004 Jun 25;117(7):849-50. doi: 10.1016/j.cell.2004.06.008.

DOI:10.1016/j.cell.2004.06.008

PMID:15210104

Abstract

RB and related proteins block transcriptional activation of genes critical to initiation of the cell cycle and suppress unwanted cell division. The circuitry controlling this response is generally conserved from humans to yeast, but no negative regulator like RB has been found in yeast. In this issue of Cell, two studies reveal that Whi5 appears to play the role of RB in preventing precocious cell cycle entry in budding yeast.

摘要

RB及相关蛋白可阻断对细胞周期启动至关重要的基因的转录激活，并抑制不必要的细胞分裂。控制这种反应的信号通路通常在从人类到酵母的生物中都是保守的，但在酵母中尚未发现像RB这样的负调控因子。在本期《细胞》杂志中，两项研究表明，Whi5在防止出芽酵母过早进入细胞周期方面似乎发挥着RB的作用。