Siah蛋白、缺氧诱导因子脯氨酰羟化酶与低氧生理反应

Siah proteins, HIF prolyl hydroxylases, and the physiological response to hypoxia.

作者信息

Simon M Celeste

机构信息

Howard Hughes Medical Institute, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

出版信息

Cell. 2004 Jun 25;117(7):851-3. doi: 10.1016/j.cell.2004.06.010.

DOI:10.1016/j.cell.2004.06.010

PMID:15210106

Abstract

New evidence suggests that at least two members of the family of hypoxia-inducible factor (HIF) prolyl hydroxylases that regulate HIF stability in response to oxygen (O2) availability are also targeted for proteosome-dependent degradation by the E3 ubiquitin ligases Siah1a and Siah2. This preview examines cellular responses to O2 deprivation (hypoxia) and the complexity of the regulation of the HIF O2 sensing pathway in mammals.

摘要

新证据表明，缺氧诱导因子（HIF）脯氨酰羟化酶家族中至少有两个成员，它们可根据氧（O₂）的可利用性调节HIF的稳定性，同时也是E3泛素连接酶Siah1a和Siah2介导的蛋白酶体依赖性降解的靶点。本综述探讨了细胞对氧剥夺（缺氧）的反应以及哺乳动物中HIF氧感应途径调节的复杂性。