青鳉（Oryzias latipes）中Dlx2、Lhx7和Lhx9的克隆及发育表达模式
Cloning and developmental expression patterns of Dlx2, Lhx7 and Lhx9 in the medaka fish (Oryzias latipes).
作者信息
Alunni Alessandro, Blin Maryline, Deschet Karine, Bourrat Franck, Vernier Philippe, Rétaux Sylvie
机构信息
UPR 2197 Développement, Evolution, Plasticité du Système Nerveux, Institut de Neurobiologie Alfred FESSARD, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette cedex, France.
出版信息
Mech Dev. 2004 Jul;121(7-8):977-83. doi: 10.1016/j.mod.2004.03.023.
We have isolated three homeodomain and LIM-homeodomain developmental transcription factors from the medaka fish (Oryzias latipes): OlDlx2, OlLhx7, and OlLhx9, and we have studied their expression patterns in the developing and adult brain. This analysis showed that OlDlx2 and OlLhx7 (together with OlNkx2.1b) delineate the subpallial divisions of the medaka telencephalon, and that OlLhx9 exhibits a typical and specific topology of expression in the pallium and diencephalic neuromeres. The expression patterns of these three genes, when compared in details with those of their tetrapod homologs, reveal both commonalities and differences in the basic organization of the developing teleost and vertebrate forebrain.
我们从青鳉鱼（Oryzias latipes）中分离出了三种同源异型结构域和LIM-同源异型结构域发育转录因子：OlDlx2、OlLhx7和OlLhx9，并研究了它们在发育中的大脑和成年大脑中的表达模式。该分析表明，OlDlx2和OlLhx7（与OlNkx2.1b一起）勾勒出了青鳉端脑的皮质下分区，并且OlLhx9在大脑皮层和间脑神经元节中表现出典型且特定的表达拓扑结构。当将这三个基因的表达模式与其四足动物同源基因的表达模式进行详细比较时，揭示了硬骨鱼和脊椎动物发育中的前脑基本组织的共性和差异。
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