Cancro Michael P, Kearney John F
Department of Pathology, University of Pennsylvania School of Medicine, John Morgan Building Room 284, 36th and Hamilton Walk, Philadelphia, PA 19104, USA.
J Immunol. 2004 Jul 1;173(1):15-9. doi: 10.4049/jimmunol.173.1.15.
Accumulating evidence indicates that positive selection events mediate differentiation, lineage commitment, and longevity of B lymphocytes. The BCR plays a central role, dictating the likelihood that newly formed cells will complete maturation, as well as whether cells persist within mature pools. Competition among B cells for limited, life span-promoting resources, which include self-ligands, lineage-specific cytokines, and innate receptor ligands, underlie these selective processes. Together, these observations suggest that positive selection is a critical feature in the establishment and maintenance of all lymphocyte pools, prompting re-evaluation of the underlying biological rationale for this process.
越来越多的证据表明，正向选择事件介导B淋巴细胞的分化、谱系定向和寿命。B细胞受体发挥核心作用，决定新形成的细胞完成成熟的可能性，以及细胞是否在成熟细胞库中持续存在。B细胞之间对有限的、促进寿命的资源（包括自身配体、谱系特异性细胞因子和固有受体配体）的竞争是这些选择过程的基础。这些观察结果共同表明，正向选择是所有淋巴细胞库建立和维持的关键特征，促使人们重新评估这一过程的潜在生物学原理。
