Sundström P, Juto P, Wadell G, Hallmans G, Svenningsson A, Nyström L, Dillner J, Forsgren L
Department of Neurology, Umeå University Hospital, Sweden.
Neurology. 2004 Jun 22;62(12):2277-82. doi: 10.1212/01.wnl.0000130496.51156.d7.
To investigate the association between human herpesviruses and multiple sclerosis (MS), as well as between measles virus and MS.
The authors identified prospectively collected serum samples from 73 MS cases and retrospective sera from 161 MS cases in two population-based serum bank registers. Analyses of IgG antibody responses in cases and matched referents were performed for Epstein-Barr virus (EBV [EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella zoster virus (VZV), and measles.
All cases showed signs of past EBV infection. High activity to EBNA-1 and HHV-6 significantly (borderline significance for HHV-6) increased the risk for MS in prospective sera. A discrepancy between activities to EBNA-1 and VCA was striking in MS samples collected less than 5 years before relapsing-remitting MS onset, where high activity to EBNA-1 significantly increased, and high VCA activity significantly decreased the risk for MS. There was no support for major causal roles for HSV, VZV, or measles.
Individuals who will develop MS exhibit an altered immune response against the EBV virus characterized by a high IgG activity to EBNA-1 in the absence of high activity to VCA, this being most pronounced in the 5-year period preceding MS onset.
研究人类疱疹病毒与多发性硬化症（MS）之间的关联，以及麻疹病毒与MS之间的关联。
作者在两个基于人群的血清库登记处中，前瞻性地鉴定了73例MS患者的血清样本，并回顾性分析了161例MS患者的血清。对病例组和匹配的对照组进行了针对爱泼斯坦-巴尔病毒（EBV [EBNA-1和VCA]）、人类疱疹病毒6型（HHV-6）、单纯疱疹病毒（HSV）、水痘带状疱疹病毒（VZV）和麻疹的IgG抗体反应分析。
所有病例均显示既往EBV感染迹象。在前瞻性血清中，对EBNA-1和HHV-6的高活性显著（HHV-6为临界显著性）增加了MS的发病风险。在复发缓解型MS发病前不到5年采集的MS样本中，EBNA-1和VCA活性之间的差异显著，其中对EBNA-1的高活性显著增加，而对VCA的高活性显著降低了MS的发病风险。没有证据支持HSV、VZV或麻疹起主要因果作用。
即将患MS的个体表现出针对EBV病毒的免疫反应改变，其特征是在对VCA无高活性的情况下对EBNA-1具有高IgG活性，这在MS发病前5年最为明显。
